Nephrotoxicity of Calcineurin Inhibitors in kidney epithelial cells is independent of Calcineurin and NFAT signaling.
A. Karolin, G. Escher, S. Rudloff, D. Sidler
The paper investigates the mechanism of CsA-induced nephrotoxicity in kidney epithelial cells and finds it is independent of the Calcineurin-NFAT pathway but involves p38 and PI3K/Akt kinases.
bioRxiv · Jul 29, 2021Pharmacology & Toxicology