Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane
A. Sabnis, K. L. H. Hagart, A. Klockner, M. Becce, L. E. Evans, R. C. D. Furniss, D. A. I. Mavridou, R. Murphy, M. M. Stevens, J. C. Davies, G. Larrouy-Maumus, T. B. Clarke, A. M. Edwards
This study reveals that colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane, not the outer membrane, and shows that murepavadin can enhance its efficacy.
eLife · Apr 6, 2021Peer-reviewedMicrobiology