Enhancer plasticity in endometrial tumorigenesis demarcates non-coding somatic mutations and 3D-genome alterations boosting the oncogenic driver ESR1
S. Gregoricchio, A. Kojic, M. Hoogstraat, K. Schuurman, S. Stelloo, T. M. Severson, T. A. O'Mara, M. Droog, A. A. Singh, D. M. Glubb, L. F. A. Wessels, M. Vermeulen, F. van Leeuwen, W. Zwart
The paper identifies enhancer plasticity and 3D-genome alterations in endometrial cancer that boost ESR1 expression through non-coding mutations and risk variants.
bioRxiv · Jul 25, 2023Cancer Biology