Intermolecular proteolytic processing of SPRING and Site-1-protease regulate SREBP signaling
S. Hendrix, J. M. E. Tan, K. Ndoj, M. Valiloo, L. F. Zijlstra, R. Ottenhoff, N. G. Seidah, A. Loregger, N. Zelcer
This study shows SPRING and S1P interact, with SPRING cleavage by S1P facilitating S1P activation, but SPRING cleavage is not essential for SREBP signaling.
bioRxiv · Mar 28, 2023 · PreprintBiochemistry