The metastable XBP1u transmembrane domain defines determinants for intramembrane proteolysis by signal peptide peptidase
S. S. Yucel, W. Stelzer, A. Lorenzoni, M. Wozny, D. Langosch, M. K. Lemberg
The paper identifies a transmembrane domain in XBP1u that mediates ER membrane insertion and shows that SPP-catalyzed proteolysis depends on TM helix dynamics and side chain interactions.
bioRxiv · Jan 29, 2019Cell Biology