PROGRAMMED AXON DEATH EXECUTOR SARM1 IS A MULTI-FUNCTIONAL NAD(P)ASE WITH PROMINENT BASE EXCHANGE ACTIVITY, ALL REGULATED BY PHYSIOLOGICAL LEVELS OF NMN, NAD, NADP AND OTHER METABOLITES
C. Angeletti, A. Amici, J. Gilley, A. Loreto, A. G. Trapanotto, C. Antoniou, M. P. Coleman, G. Orsomando
This paper investigates SARM1's multiple NAD(P)ase activities and their regulation by metabolites, identifying base exchange as a key contributor to axon death.
bioRxiv · Jul 14, 2021Biochemistry