A. M. Fleming

DNA Damage Accelerates G-Quadruplex Folding in a Duplex-G-Quadruplex-Duplex Context

This study investigates how DNA damage affects the folding kinetics of G-quadruplex sequences in a DGD motif, showing accelerated folding with specific damage types and locations.

Nanopore sequencing for the 17 modification types in 36 locations in E. coli ribosomal RNA enables monitoring of stress-dependent changes

This study uses nanopore sequencing to detect 17 RNA modifications in E. coli rRNA and shows how metabolic and cold-shock stress affect these modifications.

Nanopore sequencing for N1-methylpseudouridine in RNA reveals sequence-dependent discrimination of the modified nucleotide triphosphate during transcription

This study uses nanopore sequencing to analyze the discrimination of N1-methylpseudouridine during RNA transcription, revealing sequence-dependent incorporation patterns.

Binding of AP endonuclease-1 to G-quadruplex DNA depends on the N-terminal domain, Mg2+ and ionic strength

This paper investigates how APE1 binds and cleaves G-quadruplex DNA, showing dependence on Mg2+, K+, and the N-terminal domain.

Nanopore dwell time analysis permits sequencing and conformational assignment of pseudouridine in SARS-CoV-2

This study uses nanopore sequencing to detect pseudouridine in SARS-CoV-2 RNA by analyzing dwell times and conformational changes, identifying conserved and less conserved pseudouridine sites.

Potential G-quadruplex forming sequences and N6-methyladenosine colocalize at human pre-mRNA intron splice sites

The paper identifies colocalization of G-quadruplex forming sequences and m6A modifications at human pre-mRNA intron splice sites, suggesting a potential role in alternative splicing.