Protein thermal stability does not correlate with cellular half-life: Global observations and a case study of tripeptidyl-peptidase 1
A. M. Collier, Y. Nemtsova, N. Kuber, W. Banach-Petrosky, A. Modak, D. E. Sleat, V. Nanda, P. Lobel
This study shows that increasing the thermal stability of TPP1 does not improve its cellular half-life, suggesting that in vitro stability metrics may not predict physiological stability.
bioRxiv · Nov 11, 2019Biochemistry