Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells.
A. J. Linley, L. Karydis, A. Mondru, A. D'Avola, S. Cicconi, R. Griffin, F. Forconi, A. R. Pettitt, N. Kalakonda, A. Rawstron, P. Hillmen, A. J. Steele, D. J. MacEwan, G. Packham, I. Prior, J. Slupsky
This study uses kinobead profiling and mass spectrometry to analyze B-cell receptor signaling changes in CLL cells before and after therapy, revealing adaptive reprogramming in response to treatment.
bioRxiv · Jun 4, 2020Cancer Biology