Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP
C. M. Nadel, K. Wucherer, A. Oehler, A. C. Thwin, K. Basu, M. D. Callahan, D. R. Southworth, D. A. Mordes, C. S. Craik, J. E. Gestwicki
This study identifies phosphorylation at residue S416 on tauC3 as a mechanism that inhibits its degradation by CHIP, contributing to its accumulation in Alzheimer's disease.
bioRxiv · Aug 16, 2023 · PreprintBiochemistry