Intracellular injection of brain extracts from Alzheimer's disease patients trigger unregulated Ca2+ release from intracellular stores that hinders cellular bioenergetics
A. Pensalfini, A. R. Umar, C. G. Glabe, I. Parker, G. Ullah, A. Demuro
The paper shows that brain extracts from Alzheimer's patients trigger unregulated Ca2+ release from intracellular stores, disrupting bioenergetics and supporting a role for amyloid oligomers in neuronal toxicity.
bioRxiv · Apr 29, 2022Cell Biology