Single-cell analysis of hepatoblastoma identifies distinct tumor cell signatures that predict susceptibility to chemotherapy using patient-specific tumor spheroids
H. Song, S. Bucher, K. Rosenberg, M. Tsui, D. Burhan, S.-J. Cho, A. Rangaswami, F. W. Huang, A. Nijagal, B. Wang
This study identifies five distinct tumor cell subtypes in hepatoblastoma using single-cell analysis and shows that patient-derived spheroids can predict chemotherapy response based on transcriptomic signatures.
bioRxiv · Oct 13, 2021Cancer Biology