Novel ACE2-Independent Carbohydrate-Binding of SARS-CoV-2 Spike Protein to Host Lectins and Lung Microbiota
F. Chiodo, S. C. M. Bruijns, E. Rodriguez, R. J. E. Li, A. Molinaro, A. Silipo, F. Di Lorenzo, D. Garcia-Rivera, Y. Valdes-Balbin, V. Verez-Bencomo, Y. van Kooyk
This study identifies ACE2-independent carbohydrate-binding interactions of SARS-CoV-2 spike protein with immune lectins and lung microbiota glyco-conjugates, revealing new pathways for viral infection and immune response.
bioRxiv · May 13, 2020 · PreprintImmunology