Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability
G. Bouyer, D. Barbieri, F. Dupuy, A. Marteau, A. Sissoko, M.-E. N'Dri, G. Neveu, L. Bedault, N. Khodabux, D. Roman, S. Houze, G. Siciliano, P. Alano, R. M. Martins, J.-J. Lopez-Rubio, , C. Lavazec
This study shows that Plasmodium falciparum gametocytes maintain New Permeation Pathways (NPP) regulated by cAMP signaling, which can be reactivated by PDE inhibitors to enhance drug uptake.
bioRxiv · May 18, 2020Microbiology