HepG2 cells with knockouts of CYP51A1, DHCR24 or SC5D from cholesterol synthesis accumulate sterols influencing distinct regulatory pathways
C. Skubic, H. Trcek, P. Nassib, A. Walakira, K. Pohar, S. Petek, T. Rezen, A. Ihan, D. Rozman
This study shows that knocking out specific cholesterol synthesis enzymes in HepG2 cells leads to distinct sterol accumulations that influence different gene regulatory pathways and cell proliferation outcomes.
bioRxiv · May 19, 2023 · PreprintBiochemistry