Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation
T. M. Palhano Zanela, A. Woudenberg, K. G. Romero Bello, E. S. Underbakke
This study investigates how phosphorylation of the activation loop modulates conformational dynamics in Pyk2 kinase activation through HDX-MS and mutagenesis.
bioRxiv · Dec 3, 2022Biochemistry