Identification and characterization of neoantigen-reactive CD8+ T cells following checkpoint blockade therapy in a pan-cancer setting
K. H. Moss, U. K. Hansen, V. A. B. De Lima, A. Borch, E. S. Marquez, A.-m. Bjerregaard, O. Oestrup, A. K. Bentzen, A. M. Marquard, M. Kadivar, I. M. Svane, U. Lassen, S. R. Hadrup
The paper detects neoantigen-reactive CD8+ T cells in tumor biopsies and peripheral blood post-checkpoint blockade therapy and identifies peptide hydrophobicity and treatment-induced phenotypes as factors influencing their response.
bioRxiv · Mar 17, 2024 · PreprintImmunology