Allosteric pathways govern Gα protein coupling selectivity at promiscuous GPCRs
Tegvir S Boora, Hanyu Chen, Aaron Cho, Wijnand J. C. van der Velden, Yoon Namkung, Yubo Cao, Jay Y. Paranjpe, Franziska M. Heydenreich, Andréi S. Rodin, Sergio Branciamore, Nagarajan Vaidehi, Stéphane A. Laporte
The paper identifies allosteric pathways that determine G protein coupling selectivity in promiscuous GPCRs using a combination of mutagenesis, simulations, and machine learning.
bioRxiv · Sep 3, 2026 · PreprintPharmacology & Toxicology