Sequence modeling and design from molecular to genome scale with Evo
Eric Nguyen, Michael Poli, Matthew G. Durrant, Brian Kang, Dhruva Katrekar, David B. Li, Liam J. Bartie, Armin W. Thomas, Samuel H. King, Garyk Brixi, Jeremy Sullivan, Madelena Y. Ng, Ashley Adanna Lewis, Aaron Lou, Stefano Ermon, , Brian Hie
7B-parameter convolution-attention DNA model with 131 kb context, trained on prokaryotic genomes, performs zero-shot fitness and essentiality prediction and generates Cas loci, transposons, and 650 kb sequences.
Science · Nov 14, 2024Peer-reviewedSynthetic Biology✦ In-depth digest