BiochemistrybioRxivPreprint
Disease-causing mutations in the G protein β5 β-propeller disrupt its chaperonin-mediated folding trajectory
Mikaila Sass, Deirdre Mack, Riley A. Nickles…·Barry M. Willardson
This study uses cryo-EM and biochemistry to show how disease-causing mutations in Gβ5 disrupt its folding by CCT, leading to trapped intermediates and neurological disease.