Targeting peptide-MHC complexes with designed T cell receptors and antibodies
Amir Motmaen, Kevin M. Jude, Nan Wang, Anastasia A. Minervina, David Feldman, Mauriz A. Lichtenstein, Abishai Ebenezer, Colin Correnti, Paul Glyndwr Thomas, K. Christopher García, David A. Baker, Philip H Bradley
This paper introduces ADAPT, a deep learning framework for designing TCRs and antibodies that bind to specific pMHC targets, validated through cryo-EM structures and functional testing.
bioRxiv · Nov 19, 2025 · PreprintImmunology