Cell BiologybioRxivPreprint
Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes
Kavit Raval, Erwin Ilegems, Alexandra C. Title…·Slavica Tudzarova
This study shows that inhibiting PFKFB3 improves glucose tolerance in type 2 diabetes by restoring β-cell function and reducing dysfunctional states, with effects lasting after treatment stops.