mouse

SPACE-Tag Enables High-Throughput Spatial Chromatin Profiling With CUT&Tag

The paper introduces SPACE-Tag, a spatial CUT&Tag method for chromatin profiling, and applies it to the mouse brain to reveal age-related chromatin and transcriptome changes.

The methionine cycle sustains the mesenchymal phenotype of tumor cells and drives PDA progression

This study identifies the methionine cycle as a driver of mesenchymal traits in PDA, showing that targeting SAHH reduces metastasis and improves survival.

Citrobacter rodentium infection disrupts colonic mucus barrier function via ablation of intercrypt goblet cells

This study shows that Citrobacter rodentium infection disrupts the colonic mucus barrier by ablating intercrypt goblet cells, leading to impaired barrier integrity and enhanced pathogen colonization.

Identification of Kinome Biomarkers and Therapeutic Rescue in cGMP-Linked Retinal Degeneration

This study identifies kinome biomarkers and shows therapeutic rescue in cGMP-linked retinal degeneration using LP-CN03 in mouse models.

Epidermal Langerhans Cells Act as Neuroimmune Regulators of Pain and Itch

This study identifies Langerhans cells as immune-derived amplifiers of cutaneous sensory signaling and identifies semaphorin 7A as a mediator of LC-induced itch potentiation.

A Dynamic Stem Cell State Links Environmental Cues to Skeletal and Regenerative Fates

The paper identifies a dynamic stem cell state marked by Panx3 that responds to environmental cues and enables regeneration in aged and osteoarthritic joints.

Preserving Nanotherapy-Induced Allogeneic Murine Islet Graft Tolerance During Distal Methicillin-Resistant Staphylococcus aureus Skin Infection

This study shows that a nanotherapy (rPS) that induces islet graft tolerance can be compromised by MRSA infection, but combining it with methylprednisolone improves survival.

Network analysis of mouse brain proteomes resolves molecular and cellular endophenotypes of aging and Aβ pathology

This study uses proteomics to identify aging and Aβ-related molecular changes in mouse brains and finds they are conserved in human AD proteomes.

ER stress-associated IRE1α signalling links impaired QPRT-dependent NAD⁺ biosynthesis to reduced oocyte competence

This study links ER stress and impaired NAD biosynthesis via QPRT to reduced oocyte quality and shows that NMN supplementation improves oocyte function and early embryonic development.

CD300f is required for efficient lipid handling during cuprizone-induced demyelination

This study shows CD300f is essential for microglial lipid handling and remyelination during demyelination, with deficits in lipid metabolism and motor coordination in its absence.

Motivation-dependent communication between cortex and brainstem

The paper investigates how motivational context affects cortico-medullary communication during different types of licking behavior in mice.

Single-cell multi-omics identify OTP and NOVA1 as regulators of leptin action in hypothalamic feeding circuits

This study uses single-cell multi-omics to identify OTP and NOVA1 as key regulators of leptin action in hypothalamic feeding circuits, revealing cell-type-specific transcriptional and regulatory changes.

Neurons entrain and shape an intrinsic arteriole rhythm that distributes blood across the cortical mantle

The paper shows neurons entrain an intrinsic arteriole rhythm, shaping blood distribution and vascular responses through frequency-dependent mechanisms.

Satellite cell glucocorticoid receptor restrains myogenic commitment without mediating the effects of therapeutic glucocorticoids on muscle repair

This study shows that satellite cell glucocorticoid receptor (GR) maintains quiescence but does not mediate therapeutic GC effects on muscle repair, highlighting the importance of treatment timing and context.

Modeling circadian rhythm splitting under chronic light and the asymmetric transition kinetics between lighting conditions

The paper develops a biophysical model of the SCN to explain circadian rhythm splitting under chronic light and shows how E/I balance and chloride cotransporter dynamics drive this behavior.

Druggable CSNK2A1-MeCP2 regulatory axis links Okur-Chung neurodevelopmental syndrome with MECP2-related disorders

The paper identifies a druggable CSNK2A1-MeCP2 regulatory axis linking Okur-Chung neurodevelopmental syndrome with MECP2-related disorders through CRISPR screens and mouse models.

Deprivation of dietary fiber promotes low-grade neuroinflammation and anxiety-like behavior in mice

This study shows that depriving mice of fermentable dietary fiber leads to low-grade neuroinflammation and anxiety-like behavior, which are reversed by fiber supplementation.

Interspecific social contacts spread gut microbiota in wild rodent communities

This study shows that social interactions between different rodent species can spread gut microbiota, with stronger transmission from wood mice to yellow-necked mice.

Commensal Engineered Living Materials for Sustained Secretome Delivery and Wound Healing

This paper develops a commensal Engineered Living Material (cELM) that encapsulates bacteria to deliver a pro-healing secretome for chronic wound healing.

A three-factor model can explain symmetry breaking and the n-1 rule during X-chromosome inactivation

This paper introduces a three-factor mathematical model to explain symmetry breaking and the n-1 rule in X-chromosome inactivation by integrating Xist, an X-linked activator, and SPEN.

Hyperactivity preferentially disrupts scotopic retinal circuits in the early stages of diabetic retinopathy

This study identifies scotopic retinal circuit dysfunction in early diabetic retinopathy, linking hyperactivity to rod bipolar cell abnormalities and visual impairment under low-light conditions.

A biological light sheet links cellular voltage to mesoscopic brain dynamics

This paper introduces SPress, a method that enables high-speed, high-contrast voltage imaging of large neuronal populations in vivo with mesoscopic resolution.

TGF-b/TIF1g signaling restrains CD8+ T cell expansion while preserving cytotoxic competence

This study identifies TIF1g as a regulator of TGF-b signaling in CD8+ T cells, showing it restricts expansion while preserving cytotoxic function.

Assessing Enclosure Modifications to Enhance Accessibility for Zoo-Housed Meerkats (Suricata suricatta)

This study evaluates how accessibility modifications in zoo enclosures affect meerkat behavior, finding increased use of low areas and more frequent species-appropriate sentry behavior.

2'-O-Methylated ncRNA condensates form a recombination center for IgH synapsis

This study shows that FBL-mediated 2'-O-methylation of GLTs forms condensates that drive IgH synapsis and CSR in B cells.

stem.MAP: Identification of cell-type-specific protein complexes in mammalian embryonic stem cells.

The paper develops a proteomics-based machine learning workflow to identify cell-type-specific protein complexes in mouse embryonic stem cells, revealing 3,986 complexes and 1,388 unique interactions specific to mESC.

A biomimetic deep encoder for auditory restoration by cortical stimulation

This paper introduces Braincodec, a deep encoder that improves sound transmission via cortical stimulation, achieving high-fidelity sound reconstruction and matching non-implanted mice in sound discrimination.

Organism-dependent ecotoxicological effects of transition metal-containing layered double hydroxides

This study evaluates the ecotoxicological effects of transition metal-containing LDH nanoparticles on maize, tomato, and C. elegans, finding low phytotoxicity but greater toxicity in the nematode.

Systematic comparison of gliflozins identifies a selective anti-calcifying effect of canagliflozin beyond canonical SGLT2 inhibition

This study compares gliflozins and finds canagliflozin uniquely reduces vascular calcification through mechanisms beyond SGLT2 inhibition, affecting VSMC metabolism and calcification.

High piRNA abundance is a hallmark of evolutionarily persistent piRNA-producing loci.

The paper identifies high piRNA abundance as a key feature of evolutionarily persistent piRNA-producing loci across mouse and primate species.