Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality
Ryan J. Longchamps, Stephanie Y. Yang, Christina A. Castellani, Wen Shi, John Lane, Megan L. Grove, T.M. Bartz, Chloé Sarnowski, Kimberley Burrows, Anna L. Guyatt, Tom R. Gaunt, Tim Kacprowski, Jingyun Yang, Philip L. De Jager, Lei Yu, , Dan E. Arking
This study identifies 100 loci associated with mitochondrial DNA copy number and finds causal links between mitochondrial function and mortality.
bioRxiv · Jan 25, 2021 · PreprintGenetics