Inferring therapeutic vulnerability within tumors through integration of pan-cancer cell line and single-cell transcriptomic profiles
Weijie Zhang, Danielle Maeser, Adam Lee, Yingbo Huang, Robert F. Gruener, Israa G. Abdelbar, Sampreeti Jena, Anand G. Patel, R. Stephanie Huang
This paper introduces scIDUC, a computational framework that predicts drug response at the single-cell level by integrating single-cell transcriptomics with pan-cancer cell line data, showing high accuracy in identifying therapeutic vulnerabilities.
bioRxiv · Oct 29, 2023 · PreprintBioinformatics