Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies
Jun Liu, Ziyang Shen, Shin‐Young Park, Yanhua Dong, Na Yu, Jing Zeng, Hannah Lee, Braden Pate, Sophia Adamia, Kim Vanuytsel, Junyan Zhang, Shang-Chuen Wu, Adelaide Herman, Shiva Moein, Wenhui Liu, , Li Chai
This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.
bioRxiv · Sep 17, 2025 · PreprintCell Biology