Altered metabolic function induced by amyloid-beta oligomers and PSEN1-mutations in iPSC-derived astrocytes.
Richard J. Elsworthy, Mattéa J. Finelli, Sarah Aqattan, Connor Dunleavy, Marianne C. King, Adele Ludlam, S. L. Allen, S. Prosser, Robert E. Chen, Sandra Martínez‐Jarquín, Dong Hee Kim, J. Brown, H. Rheinallt Parri, Sarah Aldred, Eric James Hill
This study shows that astrocytes from early-onset familial Alzheimer's disease patients exhibit altered metabolism and gliosis, suggesting early metabolic changes may contribute to disease progression.
bioRxiv · Aug 23, 2023 · PreprintNeuroscience