Author

Adhithiya Charli

Iowa State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Arthi KanthasamyiD· 2 shared Huajun JiniD· 2 shared Vellareddy AnantharamiD· 2 shared Anumantha G. KanthasamyiD· 1 shared Bharathi PalanisamyiD· 1 shared Cameron Miller· 1 shared Dan Wen LouiD· 1 shared Dehui Kong· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Arthi KanthasamyORCID

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2 papers

Recent·Most cited

Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation of PKCδ and Lamin B1 Phosphorylation in Neuronal Cells: Implications for Pathogenesis of Age-related Neurodegenerative Diseases

Adhithiya Charli, Jie Luo, Bharathi Palanisamy, Emir Malovic, Zainab Riaz, Cameron Miller, Yuan-Teng Chang, Manikandan Samidurai, Gary D. Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy

This study shows mitochondrial stress triggers PKCδ activation and Lamin B1 phosphorylation, leading to nuclear membrane damage and neuronal cell death in Parkinson's disease.

Frontiers in Cellular Neuroscience · Apr 17, 2025Peer-reviewedNeuroscience

Mitochondrial Dysfunction Induces Epigenetic Dysregulation by H3K27 Hyperacetylation to Perturb Active Enhancers in Parkinson’s Disease Models

Minhong Huang, Dan Wen Lou, Adhithiya Charli, Dehui Kong, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Zhibin Wang, Anumantha G. Kanthasamy

This study shows that mitochondrial dysfunction in Parkinson’s disease models leads to H3K27 hyperacetylation, disrupting active enhancers and epigenetic regulation.

bioRxiv · Oct 17, 2019 · PreprintNeuroscience