Machine learning guided design of strong transcriptional activation domains
Marissa A. Zintel, Claire J. LeBlanc, Sanjana R. Kotha, Melvin Soriano, Rishaan J. Bansal, Daniel Aguilera, Touss Majidi, Izaiah Ornelas, Liam D. Kirkpatrick, Aditya Udupa, Gean Hu, Pooja Agarwal, Angelica W. Y. Lam, James K. Nunez, Patrick M. Shih, , Max V. Staller
The paper designs functional transcriptional activation domains using machine learning and experimental validation, finding that over 90% of predicted sequences work in yeast.
bioRxiv · Nov 2, 2026 · PreprintSynthetic Biology