mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive Immunity
Philip Samaan, Chapin S. Korosec, Patrick Budylowski, S. L. L. Chau, Adrian Pasculescu, Freda Qi, Melanie Delgado-Brand, Tulunay R. Tursun, Geneviève Mailhot, Roya Monica Dayam, Corey R. Arnold, Marc‐André Langlois, Justin Mendoza, Thomas Morningstar, Ryan Law, , Mario Ostrowski
This study examines how mRNA vaccine-induced T-cell responses correlate with neutralizing antibodies and how pre-existing immunity affects vaccine responses over time.
Journal of Virology · Jan 31, 2025Peer-reviewedImmunology