Benchmarking of Human ReadRemoval Strategies for Viral andMicrobial Metagenomics
Matthew Forbes, Duncan Y. K. Ng, Róisín M. Boggan, Andrea Frick-Kretschmer, Jillian Durham, Oliver Lorenz, Bruhad Dave, Florent Lassalle, Carol Scott, Josef Wagner, Adrianne Lignes, Fernanda Noaves, David K. Jackson, Kevin Howe, Ewan M. Harrison
The paper benchmarks human read removal methods in metagenomics, finding that high-sensitivity Bowtie2 with T2T-CHM13 reference improves removal while preserving microbial data.
Cell Reports Methods · Nov 1, 2025Peer-reviewedGenomics