IL-2 and CD40L can establish and sustain a human B cell-mediated immune regulatory network
Laurie Baert, Adrien Caffiers, Agnes Yang, SaeRome Choi, Suman Bose, SangKon Oh
This study identifies IL-2 and CD40L as key drivers of a B cell-mediated immune regulatory network by generating TIGIT+ CSM B cells that suppress inflammation and promote regulatory T cell responses.
bioRxiv · Oct 18, 2026 · PreprintImmunology