USP15 REGULATES NEUROINFLAMMATION AND DRIVES PATHOGENESIS IN SYNUCLEINOPATHIES
Nassima Fodil, Esther del Cid‐Pellitero, Valerio E. C. Piscopo, Julia Xiao Xuan Luo, Michael Wong, Jean-Frédéric Olivier, Aeshah Alluli, Irina Shlaifer, Zhipeng You, Carol X.‐Q. Chen, Nathalia Aprahamian, Yoonjeong Cha, Etienne Colette, Jonas J. Mayo, Alva Annett, , Philippe Gros
This study shows that USP15 deletion in astrocytes and microglia reduces neuroinflammation and slows synucleinopathy progression in mice, with human data linking USP15 expression to Parkinson's disease risk.
bioRxiv · Sep 12, 2026 · PreprintNeuroscience