Regulation of the Na-K-2Cl cotransporter NKCC2 by ubiquitylation
Louise Nyrup Odgaard, Agnes Thoroee, Olivier Staub, Qi Wu, Robert A. Fenton, Lena Lindtoft Rosenbæk
This study develops a mammalian cell model to investigate NKCC2 ubiquitylation, showing that K871 ubiquitylation regulates membrane localization and function, while Nedd4-2 affects total abundance but not trafficking.
bioRxiv · May 11, 2026 · PreprintMolecular Biology