Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.
Nadia M.E. Ayad, Aisha Almsoud, Johnathon N. Lakins, Ajinkya Ghagre, Allen J. Ehrlicher, Ophir D. Klein, FuiBoon Kai, Valerie Marie Weaver
The paper shows that tissue tension enables Src-mediated β-catenin phosphorylation, which is critical for mesoderm specification in human embryonic stem cells.
Developmental Cell · Jul 13, 2026Peer-reviewedDevelopmental Biology