High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX Deficiency
Swati Dubey, Simran Rai, Fabiola Guillen, Ajeeth Iyer, Su Aung, Ming Yuan, Charles G. Eberhart, Fausto J. Rodríguez
This study identifies K784-6195 as a selective cytotoxic compound for NF1-associated high-grade gliomas with ATRX deficiency, showing reduced sensitivity in wild-type ATRX cells and metabolic pathway disruption.
bioRxiv · Dec 14, 2024 · PreprintCancer Biology