Bioinformatics workflows for genomic analysis of tumors from Patient Derived Xenografts (PDX): challenges and guidelines
Xing Yi Woo, Anuj Srivastava, Joel H. Graber, Vinod Kumar Yadav, Vishal Sarsani, Al Simons, Glen Beane, Stephen C. Grubb, Guruprasad Ananda, Rangjiao Liu, Grace A. Stafford, Jeffrey H. Chuang, Susan D. Airhart, Radha Krishna Murthy Karuturi, Joshy George, Carol J. Bult
The paper develops bioinformatics workflows to analyze genomic data from patient-derived xenografts, addressing challenges like separating mouse and human reads and identifying somatic mutations without paired normal DNA.
BMC Medical Genomics · Jul 1, 2019Peer-reviewedBioinformatics