Type 2B VWD substitutions trigger enhanced macrophage-mediated clearance that is attenuated by the BT200 aptamer
Alain Chion, Ciara Byrne, Anne‐Marije Hulshof, Timon Albrecht, Bogdan Baci, Patrícia das Dores Lopes, Ellie Karampini, Lídia Puertas-Umbert, Thomas A. J. McKinnon, Jamie M. O’Sullivan, Roger J. S. Preston, Shuhao Zhu, James C. Gilbert, Bernd Jilma, Ross Baker, , James S. O’Donnell
This study shows type 2B VWD variants bind more strongly to macrophages via LRP1 and MGL receptors, and this binding is reduced by the BT200 aptamer.
bioRxiv · Sep 9, 2026 · PreprintBiochemistry