Cross-competition shapes CD8+ T cell hierarchies and differentiation after RNA vaccination
Mark J. McCarron, Milena Hornburg, Thomas D. Wu, Ann-Jay Tong, Siri Tähtinen, Martine Darwish, Emily C. Freund, Ying Feng, David Eisel, Camille-Charlotte Balança, Itai Doron, Huan Lan, Sophie M. Lehar, Tamaki Nozawa, Yoko A. Oei, , Lélia Delamarre
The paper investigates how immunodominance affects CD8+ T cell differentiation and hierarchy after RNA vaccination, finding that dominant responses influence subdominant ones through cross-competition.
bioRxiv · Oct 26, 2025 · PreprintImmunology