Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues
Adam K. Glaser, Jayaram V. Chandrashekar, Sonya Vasquez, Cameron Arshadi, Rajvi Javeri, Naveen D. Ouellette, Xiaoyun Jiang, Judith Baka, Gábor Kovács, Micah Woodard, Shamishtaa Seshamani, Kevin Cao, Nathan G. Clack, Andrew K. Recknagel, Anna Grim, , Karel Svoboda
The paper introduces ExA-SPIM, a microscope that enables high-resolution imaging of large tissue samples without sectioning, demonstrating its use on mouse brains and human white matter.
eLife · Jun 30, 2025Peer-reviewedNeuroscience