CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia
Néstor Tirado, Klaudyna Fidyt, María José Mansilla, Alba Garcia-Perez, Alba Martínez‐Moreno, Meritxell Vinyoles, Juan Alcaín, Marina García-Peydró, Heleia Roca-Ho, Narcís Fernández‐Fuentes, Mercedes Guerrero-Murillo, Aïda Falgàs, Talía Velasco-Hernández, Clara Bueno, Patrizio Panelli, , Pablo R. Menéndez
This paper develops and validates a dual-targeting CAR-T cell therapy for T-ALL that targets CCR9 and CD1a, showing improved efficacy and safety compared to single-targeting approaches.
Journal of Hematology & Oncology · Jul 1, 2025Peer-reviewedImmunology