Pdk1-dependent metabolic heterogeneity promotes aggressive colorectal cancer through cell-intrinsic interferon signaling
Jessica Calviello, Lisa Pöltl, Alessia Mira, Filippo Spini, Ainhoa Larrañaga, Lídia Fortuny, Federica Vianello, Andrea Bonilla-Díaz, Albert Alvarez-Munoz, Giulia Pazzagli, Maria Paola Serra, Nadia Ducano, Marta Ortova Gut, Eloi Casals, Anna Esteve‐Codina, , Carlos Sebastián
This study identifies Pdk1-high metabolic cancer cells in colorectal tumors that drive aggressive behavior through interferon signaling.
bioRxiv · Oct 9, 2026 · PreprintCancer Biology