Cell line identity rather than medium composition determines transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media: comparison with primary human hepatocytes
Ahmed S. M. Ali, Heike Sprenger, Albert Braeuning, Jens Kurreck
This study compares transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media, finding that cell line identity, not medium composition, is the main determinant of transcriptomic variance.
Archives of Toxicology · Jul 14, 2026Peer-reviewedCell Biology