Molecular dynamics analysis of Superoxide Dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression
Munishikha Kalia, Mattia Miotto, Deborah Ness, Sarah Opie-Martin, Thomas P Spargo, Lorenzo Di Rienzo, Tommaso Biagini, Francesco Petrizzelli, Ahmad Al Khleifat, Renata Kabiljo, Simon Topp, Keith Mayl, Isabella Fogh, Puja R. Mehta, Kelly L. Williams, , Alfredo Iacoangeli
This study uses molecular dynamics and clinical data to show structural and dynamic differences between WTL and MBR SOD1 variants, linking these to distinct ALS clinical outcomes.
Computational and Structural Biotechnology Journal · Jan 1, 2023Peer-reviewedNeuroscience