Author

Simon Topp

King's College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:protein structure· 1

Frequent Co-Authors

Alfredo IacoangeliiD· 2 shared A Nazli Basak· 1 shared Adriano Chio· 1 shared Ahmad Al KhleifatiD· 1 shared Albert Ludolph· 1 shared Aminah Ali· 1 shared Ammar Al‐ChalabiiD· 1 shared Andrea MalaspinaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioinformatics

Alfredo IacoangeliORCID

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2 papers

Recent·Most cited

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis.

Yadusayan Appulingam, John Jammal, Aminah Ali, Simon Topp, Hemali P. Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, , Oliver Pain

This paper evaluates combining expression-based surrogate variables and genotype-based principal components in differential expression analysis, finding the combined approach improves replicability and biological recall in ALS datasets.

Scientific Reports · Oct 11, 2026Peer-reviewedBioinformatics

Molecular dynamics analysis of Superoxide Dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression

Munishikha Kalia, Mattia Miotto, Deborah Ness, Sarah Opie-Martin, Thomas P Spargo, Lorenzo Di Rienzo, Tommaso Biagini, Francesco Petrizzelli, Ahmad Al Khleifat, Renata Kabiljo, Simon Topp, Keith Mayl, Isabella Fogh, Puja R. Mehta, Kelly L. Williams, , Alfredo Iacoangeli

This study uses molecular dynamics and clinical data to show structural and dynamic differences between WTL and MBR SOD1 variants, linking these to distinct ALS clinical outcomes.

Computational and Structural Biotechnology Journal · Jan 1, 2023Peer-reviewedNeuroscience