Integrated single-cell profiling of RNA and DNA interactomes reveals targetable chromatin architectures in cancer
Evgeny Deforzh, Yanhong Zhang, Hayk Mnatsakanyan, Alden John, Amelie Kinsey, Zelong Zheng, Abdellatif El Khayari, Christian E. Badr, Anna M. Krichevsky
The paper introduces SCIENCE-seq, a single-cell interactomics platform that maps RNA-RNA and DNA-DNA interactions in cancer, identifying therapeutic targets through chromatin architectures.
bioRxiv · Aug 17, 2026 · PreprintCancer Biology