Author

Alejandro Saettone

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anne‐Claude GingrasiD· 1 shared Ayala Milo· 1 shared Carol Chen· 1 shared Cassandra J. WongiD· 1 shared Edyta Marcon· 1 shared Elizabeth J. K. BhojiD· 1 shared Eric I. CamposiD· 1 shared Giovanni L. BurkeiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Anne‐Claude GingrasORCID

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2 papers

Recent·Most cited

H3.3 De Novo Mutations Alter Lysine 36 Methylation via Distinct Mechanisms

Shahir M. Morcos, Sabina Sarvan, Alejandro Saettone, Cassandra J. Wong, Scott Vo, Ayala Milo, Omar H. Bayoumy, Rajesh Angireddy, Giovanni L. Burke, Jack Greenblatt, Nada Jabado, Carol Chen, Elizabeth J. K. Bhoj, Anne‐Claude Gingras, Jean‐François Couture, Eric I. Campos

This study investigates how BLBS-causing H3.3 mutations affect H3K36 methylation and effector protein binding, revealing molecular similarities across mutations.

bioRxiv · Sep 9, 2025 · PreprintMolecular Biology

Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila

Syed Nabeel‐Shah, Jyoti Garg, Alejandro Saettone, Kanwal Ashraf, Hyunmin Lee, Suzanne Wahab, Nujhat Ahmed, Jacob L. Fine, Joanna Derynck, Shuye Pu, Marcelo Ponce, Edyta Marcon, Zhaolei Zhang, Jack F. Greenblatt, Ronald E. Pearlman, , Jeffrey Fillingham

The paper identifies RebL1 as an orthologue of human RBBP4/7 in Tetrahymena thermophila, showing its role in epigenetic regulation and oncogenic functions across species.

Nucleic Acids Research · May 4, 2021Peer-reviewedMolecular Biology