Cell-free mtDNA drives pyroptosis and inflammation in m.3243A>G mitochondrial disease models
Monica Moresco, Alessandro Rapone, Concetta Valentina Tropeano, Mariantonietta Capristo, Giada Capirossi, Danara Ormanbekova, Claudio Fiorini, Alberto Pietro Pasti, Francesco Valle, Alberto Danese, Simone Patergnani, Leonardo Caporali, Chiara La Morgia, Anu Suomalainen, Paolo Pinton, , Alessandra Maresca
This study shows that the m.3243A>G mutation increases cell-free mtDNA release, triggering pyroptosis and inflammation in MELAS models.
bioRxiv · Jul 1, 2026 · PreprintCell Biology