Alex Appert

Innate immune stress pathway activation underlies heterochromatin dysfunction pathology

The paper identifies activation of the innate immune stress pathway as a mechanism linking heterochromatin dysfunction to pathological phenotypes in C. elegans and human cells.

The SynMuvA lin-15A licenses natural transdifferentiation by antagonizing identity safeguarding mechanisms

The paper identifies lin-15A as a Licenser that facilitates transdifferentiation by antagonizing identity safeguarding mechanisms in C. elegans.

A lineage-resolved multimodal single-cell atlas reveals the genomic dynamics of early C. elegans development

This study constructs a lineage-resolved single-cell multimodal atlas of early C. elegans development, revealing genomic dynamics and zygotic genome activation mechanisms.

The histone chaperone activity of SPT2 controls chromatin structure and function in Metazoa

This study identifies the role of SPT2 in chromatin structure and function across Metazoa, showing its importance in germline development and chromatin accessibility.

Widespread transposon co-option in the Caenorhabditis germline regulatory network

The paper shows that transposon expansions in Caenorhabditis nematodes rewired germline transcriptional regulation, with one third of germline-specific promoters co-opted from MITEs.

High-resolution mapping of regulatory element interactions and genome architecture using ARC-C

The paper introduces ARC-C, a method for high-resolution mapping of regulatory element interactions and genome architecture in C. elegans, identifying ~15,000 interactions and revealing domain-level organization.

DREAM represses distinct targets by cooperating with different THAP domain proteins

The paper shows that DREAM complex represses distinct gene targets in C. elegans through cooperation with different THAP domain proteins, LIN-36 and LIN-15B, which use separate mechanisms.

The C. elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion

Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3 HDAC complex

The paper identifies a physical and functional interaction between CFP-1 and the Sin3 HDAC complex in C. elegans, showing their coordinated regulation of gene expression.

Chromatin accessibility is dynamically regulated across C. elegans development and ageing

The paper maps regulatory elements across C. elegans development and ageing, identifying promoters and enhancers and showing their dynamic accessibility linked to developmental processes.

A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress

The paper shows that C. elegans heterochromatin proteins collaborate with piRNA and nuclear RNAi pathways to silence repetitive elements and prevent germline stress.