Author

Alex Beatson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:machine learning (classical)· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Ángel Alexander CabreraiD· 2 shared Anne Elizabeth CarpenteriD· 2 shared Daniil A. BoikoiD· 2 shared Katherine TittertoniD· 2 shared Shantanu SinghiD· 2 shared Srijit SealiD· 2 shared Adit Shah· 1 shared Alex BäuerleiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPharmacology & Toxicology

Ángel Alexander CabreraORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes

Jessica Ewald, Katherine Titterton, Alex Bäuerle, Alex Beatson, Daniil A. Boiko, Ángel Alexander Cabrera, Jaime H. Cheah, Beth A. Cimini, Bram L. Gorissen, Joshua Harrill, Thouis R. Jones, Konrad J. Karczewski, Christine Crute, David Rouquié, Srijit Seal, , Shantanu Singh

Cell Painting in primary human hepatocytes exposed to 1,085 compounds detects bioactivity at lower concentrations than cytotoxicity assays and predicts cell-based, but not cell-free, ToxCast endpoints across feature extractors.

Cell Systems · Mar 27, 2026Peer-reviewedPharmacology & Toxicology✦ In-depth digest

Small molecule bioactivity benchmarks are often well-predicted by counting cells

Srijit Seal, William Dee, Adit Shah, Andrew Zhang, Katherine Titterton, Ángel Alexander Cabrera, Daniil A. Boiko, Alex Beatson, Jordi Carreras Puigvert, Shantanu Singh, Ola Spjuth, Andreas Bender, Anne Elizabeth Carpenter

The paper shows that cell counting can predict compound bioactivity as well as Cell Painting or gene expression, but Cell Painting adds unique value in protein-target-specific benchmarks.

bioRxiv · Apr 27, 2025 · PreprintBioinformatics